Ligand specificities of recombinant retinoic acid receptors RAR α and RAR β
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منابع مشابه
The Retinoic Acid Receptor (RAR ) Chimeric Proteins PML-, PLZF-, NPM-, and NuMA-RAR Have Distinct Intracellular Localization Patterns
Retinoic acid receptor (RAR ) gene rearrangement by reciprocal chromosome translocation is the molecular signature of acute promyelocytic leukemia (APL). Disruption of RAR function appears to be the likely cause of aberrant myelopoiesis observed in APL, because PML-RAR expression has been shown to deregulate the transcription of genes that control myelopoiesis. To target RAR chimeric proteins, ...
متن کاملFunction of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
Numerous congenital malformations have been observed in fetuses of vitamin A-deficient (VAD) dams [Wilson, J. G., Roth, C. B., Warkany, J., (1953), Am. J. Anat. 92, 189-217]. Previous studies of retinoic acid receptor (RAR) mutant mice have not revealed any of these malformations [Li, E., Sucov, H. M., Lee, K.-F., Evans, R. M., Jaenisch, R. (1993) Proc. Natl. Acad. Sci. USA 90, 1590-1594; Lohne...
متن کاملExpression of Retinoic Acid Receptor (RAR) α Protein in the Synovial Membrane from Patients with Osteoarthritis and Rheumatoid Arthritis
Retinoic acid receptors (RAR) are expressed in inflammatory cells and, through ligand binding, play an important role in cell proliferation and differentiation, as well as in regulation of cytokine and matrix metalloproteinase (MMP) production. Inflammatory cytokines and MMPs play a significant role in cartilage destruction in osteoarthritis (OA) and in joint destruction in rheumatoid arthritis...
متن کاملCompound mutants for retinoic acid receptor (RAR)β and RARα1 reveal developmental functions for multiple RARβ isoforms
Mice with targeted disruptions in retinoic acid receptor genes have been generated to assess the role of nuclear receptors as transducers of the retinoid signal during vertebrate development. Mice with mutations that disrupt all isoforms of the RARa, RARfl and RAR), genes as well as for the individual RARal, RARfl2 and RARe2 have been described. By breeding the RARal and RARfl strains together ...
متن کاملActivation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells
Due to the anti-proliferative and anti-apoptotic effects of retinoic acid (RA), this hormone has emerged as a target for several diseases, including cancer. However, development of retinoid resistance is a critical issue and efforts to understand the retinoid signaling pathway may identify useful biomarkers for future clinical trials. Apoptotic responses of RA are exhibited through the cellular...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2720391